Meta-Analysis on Efficacy of Meloxicillin Combined with Azithromycin in the Treatment of Streptococcus Pneumoniae Pneumonia in Children

Zheng Zhimin; Bai Ailin; Huang Yanzhi

doi:10.13407/ j.cnki. jpp.1672-108X.2022.06.011

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Meta-Analysis on Efficacy of Meloxicillin Combined with Azithromycin in the Treatment of Streptococcus Pneumoniae Pneumonia in Children

更新时间：2022-11-04

- Meta-Analysis on Efficacy of Meloxicillin Combined with Azithromycin in the Treatment of Streptococcus Pneumoniae Pneumonia in Children
- Vol. 28, Issue 6, Pages: 42-46(2022)
- 作者机构：
  
  1. 长春中医药大学,长春,130117
  2. 长春市儿童医院,长春,130061
- 作者简介：
- 基金信息：
- DOI：10.13407/ j.cnki. jpp.1672-108X.2022.06.011
  CLC：
- Published：2022，
  
  Published Online：10 June 2022，
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Zheng Zhimin, Bai Ailin, Huang Yanzhi. Meta-Analysis on Efficacy of Meloxicillin Combined with Azithromycin in the Treatment of Streptococcus Pneumoniae Pneumonia in Children. [J]. 28(6):42-46(2022)
DOI：

Zheng Zhimin, Bai Ailin, Huang Yanzhi. Meta-Analysis on Efficacy of Meloxicillin Combined with Azithromycin in the Treatment of Streptococcus Pneumoniae Pneumonia in Children. [J]. 28(6):42-46(2022) DOI： 10.13407/ j.cnki. jpp.1672-108X.2022.06.011.

摘要

目的：系统评价美洛西林联合阿奇霉素治疗小儿肺炎链球菌肺炎的疗效。方法：在PubMed、EMBase、Web of Science、the Cochrane Library、CNKI、CBM、VIP和万方数据库等中英文数据库检索国内外公开发表的关于美洛西林联合阿奇霉素治疗小儿肺炎链球菌肺炎临床效果的随机对照试验文献，根据Cochrane系统评价手册对所纳入研究进行质量评价。对纳入的文献采用RevMan 5.3软件进行Meta分析。结果：纳入6项RCT，共560例患儿。Meta分析结果显示美洛西林联合阿奇霉素的总有效率优于单用美洛西林（RR=1.27，95%CI 1.13~1.42，P<0.000，1）；退热时间（MD=-1.63，95%CI -1.71~-1.56，P<0.000，01）、咳嗽消失时间（MD=-2.19，95%CI -2.61~-1.78，P<0.000，01）、啰音消失时间（MD=-1.76，95%CI -2.32~-1.19，P<0.000，01）、X线表现消失时间（MD=-1.76，95%CI -2.33~-1.20，P<0.000，01）均比单用美洛西林时间更短，不良反应减少（RR=0.13，95%CI 0.05~0.36），差异有统计学意义（P<0.000，1）。结论：美洛西林联合阿奇霉素治疗小儿肺炎链球菌肺炎的疗效优于单用美洛西林。

Abstract

Objective: To systematically evaluate the efficacy of meloxicillin combined with azithromycin in the treatment of Streptococcus pneumoniae pneumonia in children. Methods: PubMed

EMBase

Web of Science

the Cochrane Library

CNKI

CBM

VIP and Wanfang database were retrieved to collect the randomized controlled trial (RCT) of meloxicillin combined with azithromycin in the treatment of S. pneumoniae pneumonia in children. Quality of the included literature was evaluated according to the Cochrane evaluation criteria. Meta-analysis was performed on the included literature by using RevMan 5.3 software. Results: Totally 6 RCT were extracted

including 560 children. Meta-analysis showed that the total effective rate of meloxicillin combined with azithromycin was better than that of meloxicillin alone (RR=1.27

95%CI from 1.13 to 1.42

P<0.000

duration of fever (MD=-1.63

95%CI from -1.71 to -1.56

P<0.000

01)

disappearance time of cough (MD=-2.19

95%CI from -2.61 to -1.78

P<0.000

01)

disappearance time of lung rales (MD=-1.76

95%CI from -2.32 to -1.19

P<0.000

01)

disappearance time of X-ray manifestations (MD=-1.76

95%CI from -2.33 to -1.20

P<0.000

01) were shorter than those of meloxicillin alone

and the incidence of adverse drug reactions was lower than that of meloxicillin alone (RR=0.13

95%CI from 0.05 to 0.36)

with statistically significant difference (P<0.000

1). Conclusion: The efficacy of meloxicillin combined with azithromycin in the treatment of S. pneumoniae pneumonia in children is better than that of meloxicillin alone.

关键词

美洛西林阿奇霉素肺炎链球菌肺炎Meta分析

Keywords

mezlocillinazithromycinStreptococcus pneumoniae pneumoniaMeta-analysis

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